Heart & Vascular Disease

The genetic basis of heart disease

With the help of a Medical Foundation grant, Professor Semsarian's team have made a number of important advances in both the identification of specific genes linked to heart failure and sudden death in the young, and understanding how these genes cause disease.

Recent success has been achieved with the development of a novel model which replicates severe heart failure in humans. This world first model was published in the prestigious cardiovascular medical journal Circulation, and is being used to identify key molecular steps involved in the development of heart failure, and to use this knowledge to develop new treatment and prevention strategies.